Enhanced release of itraconazole from ordered mesoporous SBA-15 silica materials.
نویسندگان
چکیده
This in vitro study reports on the enhanced release of the hydrophobic drug itraconazole from the ordered mesoporous SBA-15 silica material and on the existence of a critical mesopore diameter for enhancing release.
منابع مشابه
Molecular organization of hydrophobic molecules and co-adsorbed water in SBA-15 ordered mesoporous silica material.
The purpose of this study was to improve our understanding of the molecular organization of hydrophobic guest molecules in the presence of co-adsorbed water inside SBA-15 ordered mesoporous silica material. Understanding this adsorption competition is essential in the development of applications of controlled adsorption and desorption. The poorly water soluble drug compound itraconazole and the...
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SBA-15 is an interesting mesoporous silica material having highly ordered nanopores and a large surface area, which is widely employed as catalyst supports, absorbents, drug delivery materials, etc. Since it has a lack of functionality, heteroatoms and organic functional groups have been incorporated by direct or post-synthesis methods in order to modify their functionality. The aim of this art...
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ورودعنوان ژورنال:
- Chemical communications
دوره 13 شماره
صفحات -
تاریخ انتشار 2007